The results from the Myokardia EXPLORER- MRI sub-study are in, and there is more positive news for mavacamten (formerly known as MYK-461). According to the results of this small 35 patient study, patients who took mavacamten showed reduction of left ventricular size and wall thickness on MRI. These patients also had a reduction in their left atrial volume. All three of these measurements are predictors of poor outcome for HCM patients Additionally, this study found a reduction in certain biomarkers such as NT-proBNP, which indicate heart stress and injury.
MyoKardia (which was recently acquired by Bristol Myers Squibb) hopes that this drug will be approved by the FDA and available to American HCM patients by the end of this year.
For more on the progress of mavacamten, read these previous entries on HCMBeat:
Positive Results for MyoKardia Drug Mavacamten
MyoKardia Announces Positive Result for Mavacamten for Treatment of HOCM
MyoKardia Announces Positive Results from EXPLORER Trial
More Positive Results for MyoKardia Drug
MyoKardia’s EXPLORER Trial Big Success
DISCLOSURES: CYNTHIA BURSTEIN WALDMAN OF HCMBEAT SERVED AS A PATIENT ADVISOR ON THE STEERING COMMITTEE OF MYOKARDIA’S EXPLORER TRIAL. CYNTHIA ALSO SERVES ON MYOKARDIA’S PATIENT ADVISORY BOARD
HCM experts in the U.K. have found that extreme left ventricular wall thickness does not automatically correlate with an increased risk of sudden death. Thus, results from a recent study published in the American Heart Association’s Circulation: Arrhythmia and Electrophysiology, suggest that extreme hypertrophy NOT be the sole factor justifying the implantation of an implantable defibrillator.