Tag: Maverick

The Future of HCM Treatment

Published on by hcmbeat2 Comments

Doctors from the University of Pennsylvania this week published an overview of current therapies available for the treatment of HCM.  While this article mentions all of the old standards – beta blockers, calcium channel blockers, myectomy and alcohol ablation, the real focus is on the future of HCM treatment. In particular, the article describes several new and/or experimental therapies which look promising for the future.

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More Positive Results for MyoKardia Drug

Published on by hcmbeat6 Comments

Findings from MyoKardia’s Phase 2 Maverick clinical trial of its experimental drug mavacamten in non-obstructive HCM were announced on Monday at the online 69th Annual Scientific Sessions of the American College of Cardiology.

Dr. Carolyn Ho of Harvard’s Brigham and Women’s Hospital reported to online viewers that mavacamten was generally well tolerated.  In addition, the drug showed promising results in this Phase 2 trial intended to demonstrate the safety of the drug. In particular, some relevant additional observations were reductions in blood levels of two biomarkers of cardiac stress and injury – namely  NT-proBNP which indicates hemodynamic stress, and cardiac troponin I, which is a biomarker of myocardial injury.

These findings look promising for non-obstructive HCM patients who currently have very limited treatment options.

2 Companies Testing Drugs for HCM

Published on by hcmbeat11 Comments

Two San Francisco based companies are now conducting clinical trials for three drugs specifically targeting HCM.

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