Tag: Improve

Is a Drug for Non-Obstructive HCM on the Horizon?

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Ninerafaxstat, an investigational drug being studied by Imbria Pharmaceuticals,  may be the first drug specifically for non-obstructive hypertrophic cardiomyopathy.

The results of the Improve-HCM Phase 2 study were published last week in the Journal of the American College of Cardiology (ACC) and simultaneously presented at last week’s  meeting of the ACC in Atlanta.

The Improve study found that the drug is safe, and that patients demonstrated improvements to both exercise performance and symptoms.

The findings support advancement to a Phase 3 study to focus on efficacy of the drug.

You can read more about the IMPROVE trial here.

Drug Trial for Non-Obstructive HCM

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Yet another company is developing a new drug for hypertrophic cardiomyopathy, and this time, the drug is intended for non-obstructive HCM patients.  The company is Imbria Pharmaceuticals, and this week they announced the randomizing of the first patient in their Phase 2 study of the drug IMB-101 in patients with non-obstructive HCM.  The study, called IMPROVE-HCM, is a Phase 2 study that will look at the safety and tolerability of this drug in non-obstructed HCM patients. IMB-101 is designed to increase the efficiency of the heart’s use of energy which will be measured through cardiopulmonary exercise testing over a 12 week period.

You can read this press release and you can read more about the trial on ClinicalTrials.gov here.